To run the engine, as it is just out of a car (stock throttle body, transmission) you need the engine, trans, associated wiring harnesses, throttle pedal assembly. The rest you can (likely, verify) disable everything using EFILive or HPTuners. But you can disable security (VATS) with those and you dont have to worry about seat belts, airbags with the engine ECM. Those are handled by the BCM, completely separate module. You might lose things like cruise control and have to figure out outputs for a dash (Dakota Digital to start).