While that's a start, it's not really as refined as it should be. Problems with your plan:
1) You'll know which tune you are using. This is bigger than it sounds, because driver behavior is such a large factor. Smaller than it sounds, with your plan, because CC will eliminate driver behavior for most of the trip. But getting on and off the highway is one area where I'd expect to see a difference between the two tunes, if any.
2) You won't be repeating the same drive. I know it will be the same road, the same distance... but one direction may be uphill, the other down, one may be with the wind, the other into the wind.
3) Temperature may vary. The problem with long drives is that you start out in cold air, and the day warms up, so even though you are going through tank after tank, which is good, you aren't doing it all in the same conditions. Gains or losses, if any, tend to be pretty small for most changes, so you can lose or overestimate them in the clutter.
You will still be able to take a look... and that's exactly the sort of thing that lead me to believe the eco tune doesn't make any difference; I drove to Texas and back, alternating tunes, and when I averaged all the "eco" and all the "performance" the numbers came out pretty much the same.
On a different note, following up on a lead elsewhere in the forum, I looked around the ecomodder forum and found this really detailed post on a whole range of possible
eco mods you could look into: